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Prometrium vs Provera: progesterone capsules vs medroxyprogesterone tablets

US prescription decisions · Selected sources checked September 28, 2026

At a glance

Prometrium contains micronized progesterone in an oral capsule; Provera contains medroxyprogesterone acetate in a tablet. They are different medicines used in specified regimens, including protection against endometrial hyperplasia with estrogen under their labels. Compare the actual ingredient, treatment calendar, excipients and total regimen cost rather than matching milligrams. Sources: Prometrium source, Provera source.

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Product and supply differences
DecisionPrometriumProvera
IngredientMicronized progesteroneMedroxyprogesterone acetate
Dosage formOral capsuleOral tablet
Ingredient checkCited brand capsules contain peanut oilReview the exact dispensed tablet ingredients
Main purchase questionStrength and capsules required per prescribed cycleStrength and tablets required per prescribed cycle

Sources: Prometrium source, Provera source.

A progestogen comparison is not a hot-flash tablet comparison

These medicines may be one component of an estrogen regimen. Their endometrial uses do not make either a direct substitute for the whole estrogen-containing prescription. Ask the clinician to explain the reason for the progestogen and how its calendar fits the estrogen calendar. A box price alone leaves out both the role of the medicine and the number of doses needed. Sources: Prometrium source, Provera source.

Why the dose numbers cannot be exchanged

Progesterone and medroxyprogesterone acetate are different compounds. Their prescribed milligrams and administration patterns are not interchangeable. Do not multiply tablets, split doses or use leftover capsules to copy another regimen. Request a written calendar showing the medicine, amount and treatment days, particularly if instructions change from one cycle to the next. Sources: Prometrium source, Provera source.

Check peanut allergy and the actual formulation

The cited Prometrium label lists peanut oil in its capsules and states that it should not be used by someone allergic to peanuts. Tell the pharmacist and clinician before dispensing if this applies. A generic’s name is not enough to determine all inactive ingredients: ask them to inspect the actual manufacturer’s label. Do not assume a tablet is an acceptable alternative solely because its excipients differ. Sources: Prometrium source.

Sedation and timing belong in the choice

Prometrium’s labeling discusses dizziness and drowsiness and directs bedtime use. Explain driving, shift work or fall concerns to the clinician before changing therapy. A side effect is a reason for review, not a reason to skip required treatment days to make the prescription last longer. The alternative’s different ingredient does not guarantee that it will be better tolerated. Sources: Prometrium source.

Count a prescribed cycle before pricing it

Ask how many capsules or tablets are needed for one complete prescribed cycle, then compare equivalent periods. Include the estrogen prescription if it remains separate. Request exact brand or generic details and ask whether the plan requires a particular product. No matched current cash-price survey was obtained here; this page does not establish that either brand or generic is always cheaper.

If bleeding or tolerability prompts a switch

Describe the timing and nature of symptoms to the clinician. Do not assume all bleeding is an expected adjustment or try to solve it by changing the progestogen without assessment. Ask how to transition, what to do with old refills and when to return for review. Keep the written instructions for the complete regimen with both medicines. Sources: Prometrium source, Provera source.

Questions before filling the prescription

Is Provera generic Prometrium?

No. Medroxyprogesterone acetate and micronized progesterone are different medicines.

Can I replace a 100 mg capsule with a tablet?

There is no automatic milligram conversion. A new prescription and schedule are needed.

Does Prometrium contain peanut oil?

The cited branded capsule label does. Have the pharmacist check the exact product, especially if you have an allergy.

Is Provera the contraceptive injection?

This page concerns oral Provera tablets, not an injectable contraceptive product.

Why can the same bottle size cover different periods?

The prescribed number of treatment days per cycle determines use.

Can I stop the progestogen but continue estrogen?

Do not alter the regimen yourself. Discuss unwanted effects and an appropriate alternative with the prescriber.

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Related decisions

This is a source-based comparison, not an independent clinical review. Read the complete current product information with your clinician. Quoted supply calculations do not authorize a dose change.